An accumulation of gangliosides in brain tissue most likely arises from a deficiency of lysosomal

Question

Quizplus · Accepted Answer

The accumulation of gangliosides in brain tissue is characteristic of lysosomal storage diseases such as Tay-Sachs disease, which is caused by a deficiency of the lysosomal enzyme hexosaminidase. Hexosaminidase is required for the breakdown of gangliosides, and its deficiency leads to their accumulation.

Other answer choices:
A) Acyltransferase deficiency does not directly affect ganglioside metabolism.
B) Aryl sulfatase deficiency is associated with the accumulation of sulfatides, not gangliosides.
D) Phospholipase A2 deficiency does not directly affect ganglioside metabolism.
E) Sphingomyelinase deficiency is associated with the accumulation of sphingomyelin, not gangliosides.

An Accumulation of Gangliosides in Brain Tissue Most Likely Arises