The most serious consequence of failure of the urea cycle is

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The urea cycle is responsible for the detoxification of ammonia, a byproduct of protein breakdown, by converting it into urea which can be excreted by the kidneys. Failure of the urea cycle leads to the accumulation of toxic levels of ammonia in the blood. This can result in neurological damage, coma and even death. Thus, the most serious consequence of the failure of the urea cycle is the accumulation of ammonia (ammonium ion) in the blood.

The Most Serious Consequence of Failure of the Urea Cycle