The following are TRUE statements concerning catecholamines EXCEPT
A) dopamine cannot pass the blood brain barrier and is provided to patients with Parkinson's disease in the form of DOPA
B) the synthesis of epinephrine requires tetrahydrobiopterin, pyridoxal phosphate and SAM as cofactors
C) synthesis of epinephrine and norepinephrine takes place in the adrenal medulla
D) tyrosinase is one of the enzymes involved in catecholamine biosynthesis
E) catabolism of catecholamines involves oxidative removal of the amino groups by monoamino oxidase (MAO) and methylation of OH-groups by catechol-O-methyltransferase (cOMT)
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