Thrombin, in Its Action on Fibrinogen

Thrombin, in its action on fibrinogen

A) requires the presence of thromboplastin.
B) causes the polymerization of native fibrinogen to give fibrin.
C) hydrolyzes certain specific peptide bonds in fibrinogen.
D) in the absence of calcium ions produces a fibrin clot insoluble in urea.
E) produces a clot that has all the required components for clot retraction.