The major source of acetyl-CoA as a substrate for acetylcholine biosynthesis is

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The major source of acetyl-CoA as a substrate for acetylcholine biosynthesis is cleavage of citrate by citrate lyase. Citrate lyase cleaves citrate, which is a substrate of the citric acid cycle and produces acetyl-CoA that can be used for acetylcholine biosynthesis. Other options such as beta oxidation of free fatty acids, plasma transport of acetyl carnitine or decarboxylation of malonyl-CoA do not directly produce acetyl-CoA needed for acetylcholine biosynthesis.

The Major Source of Acetyl-CoA as a Substrate for Acetylcholine