In primary epithelial cell culture, how many cellular changes have been shown to be the minimum required for transformation into a cancer phenotype?

Question

Quizplus · Accepted Answer

It has been shown that a minimum of four cellular changes are required for transformation of primary epithelial cells into a cancer phenotype. These changes include increased proliferation, resistance to apoptosis, increased cell motility, and acquisition of chromosomal instability.

In Primary Epithelial Cell Culture, How Many Cellular Changes Have