Which two mitochondrial proteins enter the nucleus to promote DNA degradation?

Question

Quizplus · Accepted Answer

AIF (apoptosis-inducing factor) and endoG (endonuclease G) are two mitochondrial proteins that can translocate to the nucleus and promote DNA degradation during apoptosis. They are released from the mitochondrial intermembrane space following the permeabilization of the outer mitochondrial membrane. Once in the nucleus, AIF and endoG cleave and fragment DNA, leading to the characteristic DNA ladder seen in apoptotic cells. Choices B, C, D, and E are not involved in DNA degradation during apoptosis.

Which Two Mitochondrial Proteins Enter the Nucleus to Promote DNA