The key transition point in the cell cycle, subject to regulation by both protooncogenes and tumor suppressor genes, is:

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The key transition point in the cell cycle is the checkpoint between G1 and S phase, also known as the restriction point. This is where the cell decides whether to continue with the cell cycle or to exit and enter a non-dividing state called G0. Both protooncogenes and tumor suppressor genes regulate this checkpoint to ensure proper cell division and prevent uncontrolled proliferation.

The Key Transition Point in the Cell Cycle, Subject to Regulation