What are the two most likely reasons for cellular senescence (the loss of proliferative ability)?

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Quizplus · Accepted Answer

DNA damage and telomere shortening are the two primary reasons for cellular senescence. DNA damage can trigger a cellular response that leads to senescence, preventing the propagation of damaged DNA. Telomere shortening occurs with each cell division, and once telomeres reach a critically short length, it signals the cell to enter senescence, acting as a mechanism to prevent the onset of cancer.

What Are the Two Most Likely Reasons for Cellular Senescence