Which protein or enzyme would be a good target for anti-HIV therapy?

Question

Quizplus · Accepted Answer

Reverse transcriptase is a key viral enzyme that is essential for the replication of the HIV virus. It converts the single-stranded RNA genome of the virus into double-stranded DNA that integrates into the host cell chromosome. Inhibitors of reverse transcriptase have been successfully used as anti-HIV therapy, such as nucleoside analogs (e.g. AZT) and non-nucleoside reverse transcriptase inhibitors (e.g. nevirapine). Therefore, targeting reverse transcriptase is a promising strategy to treat HIV infection.

Which Protein or Enzyme Would Be a Good Target for Anti-HIV