Which Are Guidelines for Selecting Chemotherapeutic Agents to Use in Combination

Which are guidelines for selecting chemotherapeutic agents to use in combination therapy? (Select all that apply.)

A) Drugs used should have different mechanisms.
B) Each drug should be delivered by different routes.
C) Each drug should be effective.
D) Each drug should have different dosing schedules.
E) Toxicities should be minimally overlapping.