A prescriber has ordered deferasirox [Exjade] to treat iron overload associated with chronic blood transfusions. The nurse learns that the patient takes cholestyramine to reduce cholesterol. The nurse will contact the provider to request an order to:
A) increase the cholestyramine dose.
B) increase the deferasirox dose.
C) monitor cholesterol levels.
D) monitor liver function tests.

Question

Quizplus · Accepted Answer

Cholestyramine can reduce absorption of deferasirox; if the combination cannot be avoided, the dose of deferasirox should be increased. Increasing the dose of cholestyramine will only worsen the problem. It is not necessary to monitor the cholesterol level. Liver function testing should be routine with deferasirox administration, but not because of the combination of this drug with cholestyramine.

A Prescriber Has Ordered Deferasirox [Exjade] to Treat Iron Overload