Large,cumulative Doses of Doxorubicin (Adriamycin),a Cytotoxic Antibiotic,are Known to Cause

Large,cumulative doses of doxorubicin (Adriamycin) ,a cytotoxic antibiotic,are known to cause which adverse effect?

A) Severe emesis
B) Cardiomyopathy
C) Lung disease
D) Nephrotoxicity