Why Did Surgeons in the Eighteenth Century Face Incredible Difficulties

Why did surgeons in the eighteenth century face incredible difficulties?

A) They had only limited opportunities to practice surgical techniques.
B) Surgery was performed in utterly unsanitary conditions, which meant the simplest wound could become infected and lead to death.
C) They were reluctant to improve their knowledge of anatomy.
D) All operations were performed with anesthesia, but it was difficult to use and caused many deaths.