The current perspective on the etiology of Korsakoff's syndrome emphasizes the role of

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Korsakoff's syndrome is caused by long-term heavy alcohol use, which can lead to nutritional deficiencies that contribute to brain damage, particularly in regions crucial for memory and learning. While vitamin B1 deficiency (thiamine) is often implicated in cases of Korsakoff's, this deficiency is itself caused by chronic alcohol use, and the syndrome can develop even in individuals with adequate vitamin intake if they consume excessive amounts of alcohol. Disruption of neurotransmitter functioning is also a factor in chronic alcohol use, but it is not the primary cause of Korsakoff's syndrome. While head injuries that occur while intoxicated can certainly contribute to brain damage, they do not directly cause Korsakoff's syndrome.

The Current Perspective on the Etiology of Korsakoff's Syndrome Emphasizes