With regard to the diagnosis of substance dependence in the DSM-IV-TR, if tolerance and/or withdrawal are noticed, an additional specification is also made. This specification is

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The additional specification made when tolerance and/or withdrawal are present is physiological dependence. This term acknowledges the physical changes and adaptations that occur in the body due to chronic substance use, which can result in tolerance and withdrawal symptoms. Substance dependence and abuse are broader terms that can include various symptoms and behaviors related to substance use, while physiological abuse is not a recognized term.

With Regard to the Diagnosis of Substance Dependence in the DSM-IV-TR