According to the DSM-IV,the terms "substance dependence" and "substance abuse" are interchangeable.

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According to the DSM-IV, substance dependence refers to a more severe and chronic pattern of substance use, characterized by tolerance, withdrawal, and compulsive use, while substance abuse refers to a less severe and frequent pattern of use that can result in consequences such as legal, occupational, or social problems. In the DSM-IV, they are considered as separate diagnoses. However, in the DSM-5, these two terms are combined into one diagnosis of substance use disorder.

According to the DSM-IV,the Terms "Substance Dependence" and "Substance Abuse