Patients with low dopamine-receptor levels would be expected to have exaggerated responses to amphetamine or cocaine.

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Dopamine-receptors are involved in the reward pathway, and drugs like amphetamine or cocaine increase dopamine release in the brain, leading to increased activation of the reward pathway. Patients with low dopamine-receptor levels would be expected to have exaggerated responses to these drugs because the small amount of released dopamine would be more effective in activating the reduced number of receptors, resulting in a greater response to the drug.

Patients with Low Dopamine-Receptor Levels Would Be Expected to Have