In the absence (via pharmacological blockade or genetic manipulation)of dopamine transporters,cocaine is:

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Dopamine transporters regulate dopamine levels in the brain, and their absence leads to an increase in dopamine concentration. Cocaine acts by blocking dopamine transporters and thereby increasing dopamine levels, which leads to both stimulant-like effects and positive reinforcing effects. Therefore, in the absence of dopamine transporters, cocaine remains a positive reinforcer and a behavioral stimulant.

In the Absence (Via Pharmacological Blockade or Genetic Manipulation)of Dopamine