In drug-naive and opiate-dependent subjects,respectively,a mixed agonist-antagonist opiate has effects most resembling:

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In drug-naive individuals, a mixed agonist-antagonist opiate will have effects most resembling those of an opiate, as it can activate the opioid receptors and produce analgesia, sedation, and euphoria. In opiate-dependent individuals, a mixed agonist-antagonist opiate will have effects most resembling those of an opiate antagonist, as it can partially block the effects of other opioids and precipitate withdrawal symptoms. Therefore, the answer is A, an opiate; an opiate antagonist.

In Drug-Naive and Opiate-Dependent Subjects,respectively,a Mixed Agonist-Antagonist Opiate Has Effects