Agranulocytosis (loss of white blood cells)has been associated with use of the antipsychotic

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Clozapine has a rare but significant risk of causing agranulocytosis, a potentially life-threatening condition involving a severe reduction in white blood cell count. This risk has led to the implementation of a mandatory monitoring program for patients taking clozapine. Haloperidol, phenothiazines, and loxapine have not been specifically associated with a risk of agranulocytosis.

Agranulocytosis (Loss of White Blood Cells)has Been Associated with Use