The ability of liver enzymes to degrade a drug more efficiently in the continued presence of the drug is termed:

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Metabolic tolerance, also known as pharmacokinetic tolerance or dispositional tolerance, is the ability of liver enzymes to degrade a drug more efficiently in the continued presence of the drug. This leads to a decrease in the drug's effect over time, and can result in the need for higher doses to achieve the desired effect. Down regulation refers to a decrease in the number or sensitivity of receptors in response to continued drug exposure, while homeostasis refers to the body's ability to maintain stable internal conditions. Physical dependence is a state in which the body has adapted to the presence of a drug and experiences withdrawal symptoms if the drug is abruptly discontinued.

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