Researchers were searching for drugs to treat schizophrenia when they came across imipramine, which alleviated the symptoms of depression, although it was not effective against schizophrenia. It became the first of a class of drugs, all sharing a similar molecular structure, called:

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Imipramine is recognized as the first of the tricyclic antidepressants, a class of drugs characterized by their three-ring core structure, which proved effective in treating depression.

Researchers Were Searching for Drugs to Treat Schizophrenia When They