In looking for a biological cause of an erectile disorder, one would MOST productively look for a:

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A vascular problem, such as atherosclerosis or other cardiovascular issues, is the most common biological cause of erectile disorder. This is because the penis requires a healthy blood flow to achieve and maintain an erection. A neurological problem may also be a possible cause, but it is less common. Reproductive or renal problems are usually not associated with erectile dysfunction.

In Looking for a Biological Cause of an Erectile Disorder