Enzymes Are Highly Sensitive to PH and Temperature Because

Enzymes are highly sensitive to pH and temperature because

A) changes in the environment raise their activation energy.
B) changes in temperature and pH readily break their hydrogen bonds.
C) of their three-dimensional structure and side chains.
D) at extreme temperatures and pH levels, coenzymes add chemical groups to the substrate.
E) extremes of temperature and pH level change the ionization rate.