Long-term potentiation
A) was discovered by neurobiologists working with brain slice preparations.
B) involves an enhanced postsynaptic response.
C) results from repeated stimulation of a presynaptic cell.
D) involves activation of the NMDA receptor.
E) All of the above

Question

Quizplus · Accepted Answer

All of the above statements are true. Long-term potentiation (LTP) refers to a long-lasting increase in the strength of synaptic transmission between neurons. It was first observed in brain slice preparations, where repeated stimulation of a presynaptic neuron led to an enhanced postsynaptic response. LTP is dependent on the activation of the NMDA receptor, which allows calcium entry into the postsynaptic cell and leads to molecular changes that ultimately strengthen the synapse.

Long-Term Potentiation