In sickle-cell disease, one amino acid is substituted for another. This type of mutation is referred to as a _______ mutation.

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In a missense mutation, one nucleotide is substituted for another, resulting in a change in the amino acid sequence of the encoded protein. In sickle-cell disease, a missense mutation results in a substitution of the amino acid valine for glutamic acid in the beta-globin chain of hemoglobin.

In Sickle-Cell Disease, One Amino Acid Is Substituted for Another