The molecular basis of which of the following human diseases is most similar to "mad cow disease"?

Question

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Alzheimer's disease is caused by the accumulation and misfolding of a specific protein, known as amyloid-beta, in the brain. Similarly, mad cow disease (or bovine spongiform encephalopathy) is caused by the accumulation and misfolding of a specific protein, known as prion protein, in the brain. Both diseases ultimately lead to neurological dysfunction and degeneration. Sickle-cell anemia, Huntington's disease, Duchenne muscular dystrophy, and Fragile-X syndrome are all caused by genetic mutations and do not involve protein misfolding or accumulation.

The Molecular Basis of Which of the Following Human Diseases