Fragments like those now called Okazaki fragments might have been hypothesized even before they were discovered by Reiji Okazaki because
A) DNA replicates in the 3´-to-5´ direction.
B) single-stranded DNA was appearing behind DNA polymerase.
C) DNA nucleotides were being added to the 5´ end of the primer on the lagging strand.
D) RNA primase places short RNA primer sequences along the DNA molecule.
E) DNA polymerase I can connect short segments.

Question

Quizplus · Accepted Answer

Even before Okazaki's discovery, scientists had observed that single-stranded DNA is seen behind DNA polymerase during replication. This suggested the presence of fragments being synthesized on the lagging strand. Okazaki's discovery confirmed the existence of such fragments.

Fragments Like Those Now Called Okazaki Fragments Might Have Been