Should the President Die or Resign and the Vice President

Should the president die or resign and the vice president become president,what then happens to the vacant office of the vice president?

A) Nothing.It remains vacant until the next presidential election.
B) The Speaker of the House moves up to become vice president.
C) The president appoints a new vice president subject to congressional confirmation.
D) A special election is held to fill the vacancy.
E) The chief justice of the Supreme Court becomes vice president.