Which compound would be most reactive toward nucleophilic acyl addition-elimination? A)CH₃CO₂Na B)CH₃COCl C)(CH₃CO)₂O D)CH₃CONH₂ E)CH₃CO₂CH₃

Question

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The presence of the highly reactive and polarizable chloride ion makes compound B the most reactive toward nucleophilic addition-elimination. The other compounds either do not have a good leaving group (A, C, D) or have a less reactive leaving group (E).

Which Compound Would Be Most Reactive Toward Nucleophilic Acyl Addition-Elimination