The second messenger produced from the hydrolysis of PIP₂ that activates the increase of Ca⁺⁺ concentrations in the cytoplasm is: A) diacylglycerol (DAG). B) phosphatidylinositol (PI). C) phosphatidylinositol-4,5-bisphosphate (PIP₂). D) inositol-1,4,5-trisphosphate (IP₃). E) inositol-1,4-bisphosphate (IP₂).

Question

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The second messenger produced from the hydrolysis of PIP₂ that activates the increase of Ca⁺⁺ concentrations in the cytoplasm is inositol-1,4,5-trisphosphate (IP₃). The hydrolysis of PIP₂ by phospholipase C (PLC) produces two second messengers: DAG and IP₃. While DAG activates protein kinase C (PKC), IP₃ releases stored Ca⁺⁺ from the endoplasmic reticulum leading to an increase in cytoplasmic Ca⁺⁺ concentrations.

The Second Messenger Produced from the Hydrolysis of PIP2 That

The Second Messenger Produced from the Hydrolysis of PIP₂ That