Which inhibitor of protein synthesis competes with aminoacyl-tRNAs for binding to the A-site of the ribosome?

Question

Quizplus · Accepted Answer

Puromycin is a small molecule that resembles the 3'-terminal end of aminoacyl-tRNAs and is therefore able to bind to the A-site of the ribosome. Once bound, it forms a peptide bond between the nascent polypeptide chain and the amino acid on the tRNA, causing premature termination of protein synthesis. Thus, puromycin competes with aminoacyl-tRNAs for binding to the A-site of the ribosome. Erythromycin, streptomycin, cycloheximide, and tetracycline all act on other parts of the ribosome or on different steps of protein synthesis.

Which Inhibitor of Protein Synthesis Competes with Aminoacyl-TRNAs for Binding