When the thymine analog, 5-bromouracil, incorporates into DNA normally occupied by thymine, what type of mutation can occur?

Question

Quizplus · Accepted Answer

When 5-bromouracil incorporates into DNA normally occupied by thymine, it can mispair with guanine during DNA replication. This can lead to two types of mutations:
- T-A to C-G: 5-bromouracil can pair with guanine, leading to a transition mutation where a T-A base pair is changed to a C-G base pair.
- C-G to T-A: The 5-bromouracil-guanine mispair can also lead to a transversion mutation where a C-G base pair is changed to a T-A base pair.

When the Thymine Analog, 5-Bromouracil, Incorporates into DNA Normally Occupied