In ketone body biosynthesis, the HMG-CoA lyase is mechanistically the reverse of the first half of the reaction catalyzed by:

Question

Quizplus · Accepted Answer

The reverse of the first half of the reaction catalyzed by citrate synthase is the condensation of acetyl-CoA and oxaloacetate to form citrate, which is the first step in the tricarboxylic acid cycle.

Answer: D 
 Pyruvate dehydrogenase catalyzes the conversion of pyruvate to acetyl-CoA, which is the precursor molecule for ketone body biosynthesis. However, the reverse of this reaction is not mechanistically related to HMG-CoA lyase.

Therefore, the correct answer is C.

In Ketone Body Biosynthesis, the HMG-CoA Lyase Is Mechanistically the Reverse