Which of the following enzymes would be activated by phosphorylation as a result of glucagon binding to its receptor on the cell membrane?

Question

Quizplus · Accepted Answer

Glucagon binding to its receptor on the cell membrane activates the cAMP pathway, which leads to the activation of protein kinase A (PKA). PKA then phosphorylates enzymes involved in glucose metabolism, including fructose-2,6-bisphosphatase. This enzyme catalyzes the hydrolysis of fructose-2,6-bisphosphate, leading to decreased glycolytic flux and increased gluconeogenesis. Activation of pyruvate carboxylase, glycogen synthase, and pyruvate kinase is mainly regulated by other factors, such as allosteric modulation and dephosphorylation.

Which of the Following Enzymes Would Be Activated by Phosphorylation