If the non-hydrolyzable ATP analog β,γ-methylene-ATP were given to muscle cells, where would inhibition occur?

Question

Quizplus · Accepted Answer

β,γ-methylene-ATP is a non-hydrolyzable ATP analog that cannot be hydrolyzed by myosin. Therefore, inhibition would occur during the conformational change in the myosin head when ATP hydrolysis occurs. This step is critical for releasing the myosin head from actin and allowing for another cycle of cross bridge formation. Without ATP hydrolysis, the myosin head would remain attached to actin and muscle contraction would be inhibited.

If the Non-Hydrolyzable ATP Analog β,γ-Methylene-ATP Were Given to Muscle