RNA is ____ stable to alkaline hydrolysis than DNA because RNA's vicinal ____ group makes the 3'-phosphodiester bond susceptible to ____ cleavage.
A) less; 3'-OH; nucleophilic
B) less; 2'-OH; nucleophilic
C) more; 2'-OH; electrophilic
D) more; 2'-OH; nucleophilic
E) more; 3'-OH; electrophilic

Question

Quizplus · Accepted Answer

RNA is less stable to alkaline hydrolysis than DNA because of the presence of the 2'-OH group in RNA, which makes the 3'-phosphodiester bond susceptible to nucleophilic cleavage.

RNA Is ____ Stable to Alkaline Hydrolysis Than DNA Because