In an enzyme-catalyzed reaction, the lifetime of the transition state is similar to the vibrational frequencies of covalent bonds.

Question

Quizplus · Accepted Answer

This statement is true. Enzymes facilitate reactions by lowering the activation energy required to reach the transition state. The transition state is a highly unstable, reactive intermediate that requires a specific arrangement of the substrate molecules. The lifetime of this intermediate is very short, on the order of picoseconds. It is similar in duration to the time it takes for covalent bonds to vibrate in their normal modes, which is why enzymes can selectively catalyze specific chemical reactions.

In an Enzyme-Catalyzed Reaction, the Lifetime of the Transition State