The immunoglobulin domain is a stable scaffold containing two antiparallel β- sheets upon which to display hypervariable loops.

Question

Quizplus · Accepted Answer

This statement is true. The immunoglobulin domain is a structural motif that is found in many proteins, including antibodies. It is composed of two β-sheets, each made up of multiple β-strands, arranged in an antiparallel manner. The loops connecting the β-strands are known as hypervariable loops, and these are where the antigen-binding specificity of the protein is typically found. The immunoglobulin domain is a stable and versatile scaffold for displaying these loops, allowing for a diverse range of binding specificities to be generated.

The Immunoglobulin Domain Is a Stable Scaffold Containing Two Antiparallel