Proteins cannot self-assemble into a functional conformation after they have been denatured.

Question

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Proteins can self-assemble into a functional conformation after they have been denatured under the right conditions. This process is called renaturation or refolding, and it can be facilitated by chaperones or other protein-folding agents. However, in some cases, denaturation can irreversibly disrupt the protein's structure and prevent it from refolding correctly.

Proteins Cannot Self-Assemble into a Functional Conformation After They Have