Protein Folding Is a Thermodynamically Favorable Process Under Physiological Conditions

Protein folding is a thermodynamically favorable process under physiological conditions because:

A) there is an increase in entropy associated with protein folding.
B) there is a decrease in entropy of the solvent by burying hydrophobic groups within the molecule.
C) of the large negative enthalpy change associated with many noncovalent interactions.
D) no intermediate stage disulphide bonds form during the folding process.
E) all of the above.