Which of the following statements about insulin is INCORRECT?
A) In the active form it has two polypeptide chains joined by disulphide bonds.
B) It is synthesized as a random coil single chain on membrane-bound ribosomes.
C) The leader sequence is cleaved off after membrane transport.
D) The disulphide bonds form after the final proteolytic cleavage to yield mature insulin.
E) It is stored in the pancreas in an inactive form.

Question

Quizplus · Accepted Answer

The disulfide bonds in insulin form before the final proteolytic cleavage steps that yield mature insulin, not after. These bonds are crucial for the structural integrity of the insulin molecule and are formed during its precursor stages.

Which of the Following Statements About Insulin Is INCORRECT