Chromatin modifications that tend to inhibit transcription include:
A) methylation at lysine 9 or 27 of histone H3.
B) methylation at lysine 4 of histone H3.
C) ubiquitylation at lysine 119 of histone H3.
D) A, B, and C.
E) A and C.

Question

Quizplus · Accepted Answer

Methylation of histone H3 at lysine 9 or 27 and ubiquitylation of histone H2B at lysine 119 are known to inhibit transcription. Methylation of histone H3 at lysine 4, on the other hand, tends to activate transcription. Therefore, choices A and C are associated with inhibition, while choice B is associated with activation. Choice D is incorrect as it includes all three options, including choice B, which tends to activate transcription. Choice E is the correct answer as it only includes choices A and C, both of which inhibit transcription.

Chromatin Modifications That Tend to Inhibit Transcription Include