The mechanism of action of dihydrofolate reductase inhibitors used for chemotherapy is based on their ability to block the synthesis of dTMP.

Question

Quizplus · Accepted Answer

Dihydrofolate reductase inhibitors block the synthesis of tetrahydrofolate, which is necessary for the production of nucleotides such as thymidine (dTMP). Without dTMP, DNA synthesis is inhibited, leading to cell death.

The Mechanism of Action of Dihydrofolate Reductase Inhibitors Used for Chemotherapy