A major advantage of the non-depolarising neuromuscular blockers over the depolarising neuromuscular blockers is that the effect is reversible.The reason for this is that the:

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Non-depolarising blockers act as competitive antagonists at nicotinic receptors, meaning they can be displaced by acetylcholine. This allows for reversal of their effect with the administration of an acetylcholinesterase inhibitor such as neostigmine. Depolarising blockers, on the other hand, act by causing persistent depolarisation of the muscle fiber, making it difficult for acetylcholine to bind and generate an action potential. The only way to reverse their effect is through metabolism by acetylcholinesterase, which can take a long time to occur.

A Major Advantage of the Non-Depolarising Neuromuscular Blockers Over the Depolarising