To avoid tolerance associated with continuous use of nitrate patches,the patient should be advised to:

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This option suggests a nitrate-free period of about 12 hours each day, which can help prevent tolerance associated with continuous use of nitrate patches. This will allow the body to reset and reduce the risk of developing tolerance to the medication. Applying the patches only in the morning and evening (A) or only at bedtime (D) does not provide a long enough nitrate-free period to prevent tolerance. Applying the patches only when symptoms become apparent (B) may lead to inadequate symptom control and is not a recommended dosing strategy.

To Avoid Tolerance Associated with Continuous Use of Nitrate Patches,the