The two major markers of Alzheimer's disease in the brains of Alzheimer's patients are ______.

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Neuritic plaques and neurofibrillary tangles are considered the two major neuropathological hallmarks of Alzheimer's disease. Neuritic plaques are clusters of beta-amyloid protein that accumulate between the nerve cells. Neurofibrillary tangles are twisted fibers of tau protein that build up inside the nerve cells. Both of these markers are believed to contribute to the progressive brain damage seen in Alzheimer's disease. Ventriculomegaly and midline shift are nonspecific imaging findings that can be seen in a variety of brain disorders. Cerebral atrophy and tumor are also nonspecific abnormalities that can be seen on imaging but are not specific to Alzheimer's disease. Memory loss and unusual behavior are symptoms of Alzheimer's disease but not specific markers of the disease in the brain.

The Two Major Markers of Alzheimer's Disease in the Brains