The enzymes that normally trim the amyloid precursor protein (APP) to make it flush with the neuron's outer membrane are the:

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The enzymes that trim the amyloid precursor protein (APP) to make it flush with the neuron's outer membrane are called secretases. Specifically, alpha-secretase and gamma-secretase cleave APP in different regions to produce non-amyloidogenic fragments, while beta-secretase cleaves APP in a different site to produce amyloidogenic fragments that can aggregate and form plaques in Alzheimer's disease.

The Enzymes That Normally Trim the Amyloid Precursor Protein (APP)