The advantage of domperidone over metoclopramide is that it:
A) crosses the blood-brain barrier readily so it has more central side effects.
B) doesn't readily cross the blood-brain barrier so it has fewer central side effects.
C) crosses the blood-brain barrier readily so a smaller dose is required for the same antiemetic effects.
D) is safe for pregnant women in the first trimester.

Question

Quizplus · Accepted Answer

Domperidone does not readily cross the blood-brain barrier, which means it has fewer central side effects than metoclopramide. This is an advantage because central side effects of metoclopramide can include neurological symptoms such as tardive dyskinesia.

The Advantage of Domperidone Over Metoclopramide Is That It